Dr.  Yan Zhang
Senior engineer
National Microgravity Laboratory and Center of Biomechanics and Bioengineering
Institute of Mechanics, Chinese Academy of Sciences, Beijing, China, 100190
Phone: 010-86-82543795
Fax: 010-86-82543795
E-mail:zhangyan@imech.ac.cn

Area of research:
  • My research interest focus on the mechanics and kinetics of receptor-ligand interaction and their downstream signaling effects within cells using optical trap assay, fluorescence imaging techniques, or real-time confocal microscopy.
Educational background:
  • Ph.D.     Institute of Mechanics, Chinese Academy of Sciences       2009
  • M.S.       Institute of Mechanics, Chinese Academy of Sciences       2005
  • B.S.Beijing Institute of Technology  1996

Selected awards:

  • K.C.Wong Education Foundation     2011

Selected research publications:

  1. Xiao B.T., Tong C.F., Jia X.L., Guo R., Lü S.Q., Zhang Y., McEver R.P., Zhu C., and Long M.2012. Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-Selectin on the cell membrane. Biophys. J., 103: 777-785.
  2. Mao D.B., Lü S.Q., Li N., Zhang Y., and Long M. 2011. Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1. PLoS One, 6(8): e24188
  3. Zhang Y., Sun G.Y., Lü S.Q., Li N., and Long M. 2008. Low spring constant regulates P-selectin-PSGL-1 bond rupture. Biophys. J. 95: 5439-5448.
  4. Zhang Y., Lü S.Q., and Long M. 2011. Probe stiffness regulates receptor-ligand bond lifetime under forces. SCIENCE CHINA-Physics, Mechanics & Astronomy. 54(5): 923–929.
  5. Wang S. Q., Xiao W. M., Shan S. C., Jiang C. S., Zhang Y., Chen J., Zhang C. M., Chen Q., and Long M.Multi-Patterned Dynamics of Mitochondrial Fission and Fusion in a Living Cell. Plos One. Accepted.
  6. 展东颖, 章燕, 龙勉. b2整合素介导的人中性粒细胞在ICAM-1铺衬表面的铺展动力学. 医用生物力学.第26卷,第3期:14-19.
  7. Zhan D. Y., Zhang Y., and Long M. Spreading of human neutrophils onto ICAM-1-immobilized substrate under shear flow. Chin. Sci. Bull. Accepted.
  8. Lü S.Q., Zhang Y., and Long M. 2010. Visualization of Allostery in P-selectin Lectin Domain Using MD Simulations.Plos One. 5(12): e15417.
  9. Li H., Chen J., Zhang  Y. , Sun  S. J., Tao Z. L. and Long M. 2010. Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells. SCIENCE CHINA-Life Sciences. Vol.53 No.9: 1085–1091.
  10. Wang S.Q., Fu C.F., Zhang Y., Chen Q., and Long M. 2010. Dynamics of morphological changes for mitochondrial fission and fusion. Sci. China Ser. G-Phys. Mech. Astron., 53(4): 680-689.
  11. Sun G.Y., Zhang Y., Huo B., and Long M. 2009. Parametric analysis for monitoring 2D kinetics of receptor-ligand binding.Cell. Mol. Bioengi., 2(4): 495-503.
  12. Sun G.Y., Zhang Y., Huo B., and Long M. 2009. Surface-bound selectin-ligand binding is regulated by carrier diffusion. Eur. Biophys. J., 38(5): 701-711.
  13. Yang F, Gao YX, Zhang Y, Chen J, and Long M. 2009. Developing a microfluidic-based system to quantify cell capture efficiency. Sci. China Ser. C. 52: 173-181.
  14. Wang SQ, Jiang CS, Zhang Y, Chen J, Wang B, Chen Q, and Long M. 2008. Membrane deformability and membrane tension of single isolated mitochondria. Cell. Mol. Bioengi. 1: 67-74.
  15. Wu L, Xiao BT, Jia XL,Zhang Y, Lü SQ, Chen J, and Long M. 2007. Impacts of carrier stiffness and microtopology on 2D kinetics of P-selectin-PSGL-1 interactions. J. Biol. Chem. 282(13): 9846–9854.
  16. 章燕,叶志义,霍波,孙淦云,龙勉.2005.应用光阱技术测量P-selectin/PSGL-1键解离的断裂力.生物医学工程学杂志. 第22卷,第5期:961-965.
  17. 李宁,章燕,孙淦云,龙勉.2007.非特异性相互作用的断裂力与寿命测量.医用生物力学. 第22卷,第1期:35-39.

 

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