Dr.  Shouqin LÜ
National Microgravity Laboratory and Center of Biomechanics and Bioengineering
Institute of Mechanics, Chinese Academy of Sciences, Beijing, China, 100190
Phone: 010-86-82543778
Fax: 010-86-82543795
E-mail: lsq@imech.ac.cn

Area of research:
  • Focusing on structure-function relationship of adhesion molecules of selectin and beta2 integrins using molecular dynamics simulations and biomechanical assays such as atomic force microscopy (AFM) and Flow chamber.
Educational background:
  • Ph.D.  Institute of Mechanics, Chinese Academy of Sciences    2006
  • M.S.   Beijing Institute of Technology                         1998
  • B.S.   Yantai Normal College                                1995

Selected awards:

  • Guo Yonghuai Award(1st Prize),Institute of Mechanics, CAS   2006
  • Liu Yongling Award, CAS                                  2006

Selected research publications:

  1. Lü S.Q., and Long M. 2004. Forced extension of P-selectin construct using steered molecular dynamics. Chin. Sci. Bull., 49(1): 10-17.
  2. Lü S.Q., Long M. 2005. Forced dissociation of selectin-ligand interactions using steered molecular dynamics simulation. MCB: Mol Cell Biomech, 2(4): 161-177.
  3. Lü S.Q., Ye Z.Y., Zhu, C., and Long M. 2006. Quantifying the effects of contact duration, loading rate and approach velocity on P-selectin-PSGL-1 interactions using AFM. Polymer, 47: 2539-2547.
  4. Long M., Lü S.Q., and Sun G.Y. 2006. Kinetics of receptor-ligand interactions in immune responses. Cell Mol Immunol, 3(2): 79-86.
  5. S.Q.,Zhang Y., and Long M. 2010. Visualization of allostery in P-selectin lectin domain using MD simulations. PLoS One, 5(12): e15417.
  6. Zhang M.H., Lü S.Q., Li G.W., Yu X., Sun W.N., Tang Z.C., Long M., and Su W.A. 2010. Residue identification in molecular aqueous pathway determines water permeability of rice PIPs. J. Biol. Chem., 285: 41982-41992. (co-first author)
  7. Mao D.B., Lü S.Q., Li N., Zhang Y., and Long M. 2011. Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1. PLoS One, 6(8): e24188 (Co-corresponding author).
  8. Kang Y.Y., Lü S.Q., Ren P., Huo B., and Long M. 2012. Shear- and stretch-induced dissociation of P-selectin/PSGL-1 complex using molecular dynamics simulation. Biophys. J., 102: 112-120. (Co-first author)
  9. Lü S.Q., and Long M. 2012. Molecular dynamics simulation and molecular biomechanics. Acta Biophysica Sinica (In Chinese), 28(1): 6-14.
  10. Xiao B.T., Tong C.F., Jia X.L., Guo R., Lü S.Q., Zhang Y., McEver R.P., Zhu C., and Long M.2012. Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-Selectin on the cell membrane. Biophys. J., 103: 777-785.
  11. An H.L.Lü S.Q., Li J.W., Meng X.Y., Zhan Y., Cui M., Long M., Zhang H.L., Logothetis D.E., The Cytosolic GH Loop Regulates the Phosphatidylinositol4,5-Bisphosphate-induced Gating Kinetics of Kir2 Channels.J. Biol. Chem., Accepted

Chinese Version