生物力学数据平台

吕守芹  博士 研究员 中国科学院力学研究所, 生物力学与生物工程中心 中国科学院微重力重点实验室, 中国.北京, 100190 电话: 010-86-82543778 传真: 010-86-82543795 E-mail:lsq@imech.ac.cn

研究方向:

• 结合分子动力学模拟和分子生物力学实验方法考察细胞粘附分子选择素、beta2整合素的结构-功能关系。

教育经历:

• 博士  中国科学院力学研究所                 2006
• 硕士   北京理工大学                        1998
• 学士   烟台师范学院（现鲁东大学）          1995

主要奖励:

• 中国科学院力学研究所，郭永怀奖学金一等奖    2006
• 中国科学院刘永龄冠名奖                      2006

主要论文:

1. Lü S.Q., and Long M. 2004. Forced extension of P-selectin construct using steered molecular dynamics. Chin. Sci. Bull., 49(1): 10-17.
2. Lü S.Q., Long M. 2005. Forced dissociation of selectin-ligand interactions using steered molecular dynamics simulation. MCB: Mol Cell Biomech, 2(4): 161-177.
3. Lü S.Q., Ye Z.Y., Zhu, C., and Long M. 2006. Quantifying the effects of contact duration, loading rate and approach velocity on P-selectin-PSGL-1 interactions using AFM. Polymer, 47: 2539-2547.
4. Long M., Lü S.Q., and Sun G.Y. 2006. Kinetics of receptor-ligand interactions in immune responses. Cell Mol Immunol, 3(2): 79-86.
5. Lü S.Q.,Zhang Y., and Long M. 2010. Visualization of allostery in P-selectin lectin domain using MD simulations. PLoS One, 5(12): e15417.
6. Zhang M.H., Lü S.Q., Li G.W., Yu X., Sun W.N., Tang Z.C., Long M., and Su W.A. 2010. Residue identification in molecular aqueous pathway determines water permeability of rice PIPs. J. Biol. Chem., 285: 41982-41992. (co-first author)
7. Mao D.B., Lü S.Q., Li N., Zhang Y., and Long M. 2011. Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1. PLoS One, 6(8): e24188 (Co-corresponding author).
8. Kang Y.Y., Lü S.Q., Ren P., Huo B., and Long M. 2012. Shear- and stretch-induced dissociation of P-selectin/PSGL-1 complex using molecular dynamics simulation. Biophys. J., 102: 112-120. (Co-first author)
9. Lü S.Q., and Long M. 2012. Molecular dynamics simulation and molecular biomechanics. Acta Biophysica Sinica (In Chinese), 28(1): 6-14.
10. Xiao B.T., Tong C.F., Jia X.L., Guo R., Lü S.Q., Zhang Y., McEver R.P., Zhu C., and Long M.2012. Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-Selectin on the cell membrane. Biophys. J., 103: 777-785.
11. An H.L.Lü S.Q., Li J.W., Meng X.Y., Zhan Y., Cui M., Long M., Zhang H.L., Logothetis D.E., The Cytosolic GH Loop Regulates the Phosphatidylinositol4,5-Bisphosphate-induced Gating Kinetics of Kir2 Channels.J. Biol. Chem., Accepted

English Version